The Correlation of Plasma Malondialdehyde Level Elevation with Infarct Volume on Brain MSCT and BI among patients with Acute Ischemic Stroke

Retnaningsih Retnaningsih


Stroke is neurovascular impairment, contributing to the forth common cause of death in the world. Furthermore, stroke is the most common cause of disability. Acute ischemic stroke (AIS) were defined as broaden infarct after 48-72 hours of onset. Oxidative stress plays an important role in brain damage after stroke. During oxidative stress, free radicals were released by lipid peroxidation with malondialdehyde (MDA) as the marker. The objective of this research is to analyze the correlation of plasma malondialdehyde level elevation with infarct volume on brain MSCT and BI among patients with acute ischemic stroke. This is an observational study with cross sectional design conducted in Stroke Unit, Dr. Kariadi General Hospital Semarang. Fourty-three patients with AIS within ≤ 72 hours of onset were include in this study. The diagnosis and the infarct volume were confirmed by MSCT. MDA level was measured by using TBARS method. The clinical neurology was assesed by Bartel Index (BI). The statistical and correlation analysis were performed by Spearman’s Rho test. There is no significant differences in plasma MDA level elevation with infarct volume size. There is significant correlation between infarct volume and BI at admission. There is no significant correlation between plasma MDA level elevation and infarct volume also BI admission. There is no significant correlation between plasma MDA level elevation and infarct volume size. There is significant correlation between infarct volume size and BI admission.


Plasma MDA level, Acute ischemic stroke, Infarct volume, Brain MSCT

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