Effect of Snakehead Fish Extract Supplementation in Protein Status, Oxidativestress Status, Antioxidant Status, and Clinical Outcome of Acute Ischemic Stroke

Retnaningsih Retnaningsih, Hertanto WS, Suharyo H, Amin Husni


In acute ischemic stroke, reperfusion paradoxically leads to heightened free radical formation, inducing oxidative stress that exacerbates brain damage. Malondialdehyde (MDA) reflects lipid peroxidation and oxidative stress, while total antioxidant status (TAS) indicates defense against damage. Serum proteins like albumin, transthyretin, retinol binding protein, and transferrin play multifunctional roles in neuroprotection and antioxidation. This study investigates the impact of snakehead fish extract (SFE), rich in proteins, on protein levels, TAS, malondialdehyde, and stroke severity. SFE's potential to modulate these factors offers insights into stroke management. By enhancing antioxidant capacity and deciphering protein influences, this research contributes to strategies countering oxidative damage and advancing acute stroke interventions.

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