Optogenetics in Neurology and Neuroscience

Taruna Ikrar


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Zhang F, Gradinaru V, Adamantidis AR, et al. Optogenetic interrogation of neural circuits: technology for probing mammalian brain structures. Nat Protoc. 2010;5(3):439–456.

Rossi MA, Calakos N, Yin HH. Spotlight on Movement Disorders: What optogenetics has to offer. Mov Disord. 2015;30(5):624–631.

Tonnesen J. Optogenetic cell control in experimental models of neurological disor-ders. Behav Brain Res 2013; 255:35–43.

Kravitz AV, Freeze BS, Parker PR, Kay K, Thwin MT, Deisseroth K, et al. Regulation ofparkinsonian motor behaviours by optogenetic control of basal ganglia circuitry.Nature 2010;466:622–6.

Doroudchi MM, Greenberg KP, Liu J, Silka KA, Boyden ES, Lockridge JA, et al.Virally delivered channelrhodopsin-2 safely and effectively restores visual func-tion in multiple mouse models of blindness. Mol Ther: J Am Soc Gene Ther2011;19:1220–9.

Busskamp V, Duebel J, Balya D, et al. Genetic reactivation of cone photoreceptors restores visual responses in retinitis pigmentosa. Science. 2010;329(5990):413–417.

Williams JC, Denison T. From optogenetic technologies to neuromodulation therapies. Sci Transl Med. 2013;5(177):176-177.

Shiri Z, Manseau F, Levesque M, Williams S, Avoli M. Interneuron activity leads toinitiation of low-voltage fast-onset seizures. Ann Neurol 2015;77:541–6.

Yekhlef L, Breschi GL, Lagostena L, Russo G, Taverna S. Selective activationof parvalbumin- or somatostatin-expressing interneurons triggers epilep-tic seizurelike activity in mouse medial entorhinal cortex. J Neurophysiol2015;113:1616–30.

Wykes RC, Kullmann DM, Pavlov I, Magloire V. Optogenetic approaches to treat epilepsy. Journal of Neuroscience Methods 2016;260:215–220.

Krook-Magnuson E, Armstrong C, Oijala M, Soltesz I. On-demand optogenetic controlof spontaneous seizures in temporal lobe epilepsy. Nat Commun 2013;4:1376.

Ellender TJ, Raimondo JV, Irkle A, Lamsa KP, Akerman CJ. Excitatory effectsof parvalbumin-expressing interneurons maintain hippocampal epileptiformactivity via synchronous afterdischarges. J Neurosci: Off J Soc Neurosci 2014;34:15208–22.

Ledri M, Madsen MG, Nikitidou L, Kirik D, Kokaia M. Global optogenetic activation of inhibitory interneurons during epileptiform activity. J Neurosci: Off JSoc Neurosci 2014;34:3364–77.

Wykes RC, Kullmann DM, Pavlov I, Magloire V. Optogenetic approaches to treat epilepsy. J Neurosci Methods 2016;260:215–220.


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